Mine ran very rough (smooth engine but the rest of the bike vibrated like who wrote it under way) after the install of the timing wheel and then worse after the Lloyds air filter. I ended up taking the timing wheel off and it helped things a lot.
All that for this. I have a Doebeck AFR+ gen 4. It is supposed to keep the A/F ratio in a certain range when set. Well it probably did that, but needed to be set a little richer for the set up I had acquired over time. Now all is smooth and I wonder if the timing wheel would be OK now, oh well too late. The lie-o-meter loves it, shows over 50 MPG, but calculated is in the 40 MPG range now.
Witchdoctors says a controller is recommended with the filter, and unplugging O2 sensors isn't always a guarantee, so, get a controller, with the filter. PCV will need a dyno and need redone after further upgrades, but yes you'll see gains and better throttle with the two. If your gonna do it, then go with the best bang for the buck. Pay me now or pay me later as the saying goes.
A few tuners are out there, so check them out and see what seems to be best for where you want to end up.
Welcome to the mayhem.
Cheers